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Real Madrid vs. Juventus Prediction, Match Preview and Tips, 22 October 2025

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A group of Real Madrid footballers celebrate a goal during the UEFA Champions League Round of 16 first leg match
D. Canales Carvajal / Alamy Stock Photo

The Champions League clash on 22 October 2025 at the iconic Estadio Santiago Bernabeu promises an electrifying encounter. Under the stewardship of Xabi Alonso, Real Madrid sits comfortably in 2nd position with 6 points, buoyed by their attacking flair, averaging 3 goals per match over the last five games. Meanwhile, Juventus, struggling at 23rd with only 2 points, will be desperate for a win under Igor Tudor.

The weather, with overcast clouds and a chilly 11°C, could play a role in this high-stakes game. Referee Slavko Vincic will oversee the proceedings.

Match Facts:

  • Kylian Mbappe has netted 5 goals in 2 matches.
  • Dusan Vlahovic has scored 2 goals in 2 matches.

Prediction: Real Madrid to edge out Juventus, but expect both teams to score.

Real Madrid vs. Juventus Prediction & Tip

The recommended bet is that both teams will score (BTTS – Yes). Given the attacking prowess of both teams, especially with players like Kylian Mbappe and Dusan Vlahovic in fine form, goals from both sides are highly likely.

Real Madrid
Juventus
Odds are subject to change. Last updated October 21, 2025 10:07 pm
  • Real Madrid’s strong attacking record averages 3 goals per match.
  • Juventus will be pushing hard to secure a win, likely leaving gaps in defence.
  • Both top scorers, Mbappe and Vlahovic, are in excellent form with multiple goals in the tournament.

Expect an engaging match where both teams find the net.