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Lazio vs. Roma Prediction, Match Preview and Tips, 21 September 2025

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Wesley of A.S. Roma celebrates after scoring the goal of 1-0 during the 1st day of the Serie A, 2025
Domenico Cippitelli / Alamy Stock Photo

The Eternal City braces itself for another thrilling derby as Lazio hosts Roma at Stadio Olimpico. Set against the backdrop of light rain, this Serie A clash promises intense action. With Roma currently in 6th place and Lazio trailing in 12th, both teams are eager to climb the standings.

Roma, the bookmaker’s favorite, boasts a strong recent form, with three clean sheets in their last five games. Lazio, under Maurizio Sarri, will look to capitalize on home advantage despite their mixed results.

Match Facts

  • Less than 2.5 goals have been scored in 75% of their past eight encounters.
  • Their last meeting at this venue ended in a 1-1 draw.
  • Lazio have a praiseworthy home record.

Anticipate a fiercely contested battle with early goals potentially setting the tone.

Lazio vs. Roma Prediction & Tip

The recommended tip for this clash is to bet on over 2.5 goals in the first half. Both Lazio and Roma play an open and fast style of football, especially in the first half. This aggressive approach often leads to early goals.

Odds are subject to change. Last updated September 19, 2025 8:36 am.
  • Both teams push forward and create chances, leaving space in defense.
  • Early pressure from both sides can lead to quick goals.
  • Lazio at home often attack strongly, while Roma try to respond quickly.

Expect a high-energy start with early fireworks, making over 2.5 goals in the first half a solid bet.